Results of the 2009 "Monitoring the Future" (MTF) study document the disturbing prevalence among teens of abuse of prescription and over-the-counter drugs. The data show, for example, that seven of the substances most commonly abused by high school seniors are pharmaceuticals. Many parents believe they are powerless to influence their teens. However, research makes clear that parents remain the single most powerful influence in their kids' lives. This paper offers some tips for parents on how to talk to their teens about drug use. (Contains 4 figures.)