This publication is intended to provide a set of quality guidelines for developing and evaluating student scientific investigations and surrounding course content that are parts of courses (or other learning experiences) delivered online at a distance from the instructor and a traditional science classroom. To be inclusive of the range of approaches that are possible, the authors adopt the term "student scientific investigations" rather than "laboratory." The authors first review the relevant research literature describing the current state of traditional classroom labs and new developments in remote, online, and simulated labs. The remainder of the publication is divided into three major sections: (1) Guidelines for Student Scientific Investigations; (2) Learning Goals for Student Scientific Investigations; and (3) Curriculum Design and Integration Standards. Two appendices are included: (1) Integrated Lab Program Samples; and (2) Resources Cited by the National Resource Council in Support of all Goals. (Contains 1 footnote.) [This paper was written with Allison Powell.]