Launched in 2006 to address issues of national competitiveness and equity in science, technology, engineering, and mathematics (STEM) fields, the National Science Foundation-funded Model Replication Institutions (MRI) program sought to improve the quality, availability, and diversity of STEM education. The project offered technical assistance to replicate and disseminate the findings of successful NSF initiatives at Minority-Serving Institutions (MSIs). In particular, MRI builds on best practices in STEM undergraduate education identified by the National Science Foundation initiative Model Institutions of Excellence (MIE). Through MRI, nine MSIs replicated aspects of the Model Institutions of Excellence model to improve their STEM programs. The recommendations offered in this paper are based on their experience in adapting the model to support their STEM goals and may be instructive for other institutions engaged in similar work.