The purpose of this Guide is to provide Mathematics and Science Partnership (MSP) project officials and evaluators with clear, practical advice on how to conduct rigorous evaluations of MSP projects at low cost. Specifically, this is a how-to Guide designed to enable MSP grantees and evaluators of MSP projects to answer questions about the projects' impact, such as: "Does this MSP project improve student math and science achievement and increase teacher content knowledge; if so, by how much?" The resulting knowledge about "what works" can then be used by schools and districts as an effective, valid tool in ensuring: (1) that their math and science teachers are highly qualified; and (2) that their students are proficient in math and science, both of which are central goals of American education policy. This Guide provides concrete, step-by-step advice, as follows: (1) Find a researcher with expertise in conducting rigorous impact evaluations to include on the study team; (2) Decide what research question(s) the study seeks to answer; (3) Decide on the study design; (4) Gain the cooperation of teachers and school officials; (5) Allocate teachers to the program and control (or matched comparison) groups; (6) Collect the data needed to measure the MSP project's effectiveness; and (7) Analyze and report the study's results. Appendixes include: (1) Websites listing rigorous evaluations, which you can use to identify capable researchers for your study team; and (2) Illustrative example of agreement assuring school district you will protect confidential student data. (Contains 14 notes.) [This publication was produced by the Coalition for Evidence-Based Policy, in partnership with the National Opinion Research Center (NORC) at the University of Chicago.]