As part of its ongoing programs in digital scholarship and the cyberinfrastructure to support teaching, learning and research, the Council on Library and Information Resources (CLIR) in cooperation with the National Endowment for the Humanities (NEH) held a symposium on September 15, 2008 in which a group of some 30 leading scholars was invited to articulate the research challenges that will use the new media to advance the analysis and interpretations of text, images and other sources of interest to the humanities and social sciences and in so doing, pose interesting problems for ongoing computational research. White papers were commissioned to help frame the issues. This report contains the final versions of those papers, as well as an account of the day's discussion and a summary of a report by Diane Zorich on digital humanities centers. (Papers include: (1) Asking Questions and Building a Research Agenda for Digital Scholarship (Amy Friedlander); (2) Tools for Thinking: ePhilology and Cyberinfrastructure (Gregory Crane, Alison Babeu, David Bamman, Lisa Cerrato, and Rashmi Singhal); (3) The Changing Landscape of American Studies in a Global Era (Caroline Levander); (4) A Whirlwind Tour of Automated Language Processing for the Humanities and Social Sciences (Douglas W. Oard); (5) Information Visualization: Challenge for the Humanities (Maureen Stone); (6) Art History and the New Media: Representation and the Production of Humanistic Knowledge (Stephen Murray)l and (7) Social Attention in the Age of the Web (Bernardo A. Huberman.) (References, figures and footnotes are included by individual paper.)