This report summarizes three separate evaluative research projects, which address different but related aspects of Indiana's Twenty-first Century Scholars program, a state-supported effort to promote pre-college preparation and postsecondary access for low-income students. Considered collectively, the studies support the following assertions: (1) the Scholars program promotes enrollments and success in academically challenging high school coursework among low-income and first-generation students; (2) the Scholars program allows participating students and families to view college as a real possibility; (3) Relationships forged through the program are reported by students, families and staff to yield personal and academic benefit beyond college enrollment; (4) Although a growing number of Indiana colleges and universities now provide targeted support services for Twenty-first Century Scholars, availability varies widely between campuses and few institutions have developed Scholar-specific programs to ease transition into and bolster success in college; (5) Schools and institutions are challenged by a lack of current identification and tracking data; and (6) Despite program limitations, its component elements of pre-college service/preparation, financial aid, and targeted academic/social supports make a measurable difference in improving the success rate of low-income and first-generation students. Recommendations are offered for improving practice and policies. (Contains 31 footnotes and 8 figures.)