What skills and competencies do high school students need to master for future success? And what can high schools do to develop these skills? Research on skills has tended to focus either on college readiness or on workplace readiness, often in isolation and frequently without reference to what the broader field of youth development tells us every young person needs to make a successful transition to adulthood. Additionally, the emphasis has been on cognitive skills, and on how students, particularly those with challenges, leave high school intellectually unprepared for college or work. There has been less focus on the specific competencies, including non-cognitive skills, which are necessary to foster that preparation. This brief draws on research across the three fields of college readiness, workplace readiness, and youth development, to identify strategies high schools can employ to foster both cognitive and non-cognitive competencies in their students, and highlights practices that are particularly effective for students facing specific challenges. (Contains 1 chart.) [This brief draws from the report, "A Developmental Perspective on College and Workplace Readiness," (Laura Lippman, Astrid Atienza, Andrew Rivers, and Julie Keith.)]