This issue brief examines the role of central office administrators in the reinvention process and what research and experience matters for expanding student learning. The brief includes examples from central office reinvention efforts currently planned or under way in Atlanta Public Schools, New York City Public Schools, and Oakland Unified School District (California). These districts are highlighted because during the past several years, each of them has made significant investments in central office reinvention as an important educational improvement strategy; accordingly, these districts arguably provide examples of central office reinvention efforts that are fairly well along, at least in their conceptualization. These districts also represent a range of midsized to large urban contexts; therefore, their examples may resonate directly with leaders across different types of urban and suburban districts and relatively large rural districts. The brief concludes with key questions for education leaders to consider regarding the role of central office administrators in expanding learning districtwide. (Contains 1 endnote.) [This issue brief was administered by Learning Point Associates in partnership with the Southwest Educational Development Laboratory (SEDL), under contract with the Office of Elementary and Secondary Education of the U.S. Department of Education. ]