Young people who live in rural areas are less likely to finish high school and to complete college than their urban and suburban peers. These adolescents are also more likely to use drugs and alcohol: rural adolescents between the ages of 12 and 17 have the highest levels of drug use in this age group. Out-of-school-time programs in rural areas can provide healthy and constructive activities that offer productive ways for children and youth to spend their time, build positive relationships, and receive academic support. This brief highlights the challenges faced by rural out-of-school programs, including: (1) Rural programs serve at-risk populations; (2) Geographic isolation can contribute to poor access to transportation; (3) Rural programs have limited funding; and (4) Rural programs have fewer highly trained staff members. Five strategies are offered for obtaining resources and strengthening rural out-of-school programs: (1) Consider building coalitions to help with transportation; (2) Identify possible funding sources; (3) Increase the number of trained staff members; (4) Use existing volunteer organizations to recruit staff; and (5) Maximize resources. Howard Rosen, Director of Generacion Diez, an after-school program that serves the migrant community in Adams County, Pennsylvania, is interviewed for reflections on the success of this rural out-of-school program. (Contains 71 endnotes.)