Students in the United States have higher educational aspirations than ever before. One barrier for Latino high school students are the myths, misconceptions, and absence of accurate information about what it takes to get to college. This issue is particularly critical for students who are the first in their families who have the opportunity to go to college. Course requirements for college admissions, the required admissions tests, and the intricacies of applying for financial aid are some of the areas that students and their families are expected to understand. This document describes how several ENLACE sites worked to fill these gaps by creating college-focused centers in local high schools. The following three good practices are detailed: (1) Serve students across the P-20 educational pathway; (2) Engage parents, families, and communities; and (3) Support policy change for impact. A list of resources for more research and good practices for developing a college-focused center is included.