Universities have come under serious attack because of their lackluster response to HIV/AIDS. The article endevours--from an institutional perspective--to what extent National Open University of Nigeria (NOUN) has responded to this challenge. This is done by first, highlighting NOUN basic structures that position it to respond better to the epidemic; second, by assessing HIV/AIDS institutional policy framework put in place. It concludes that although NOUN has identified the impact the epidemic has on the university, it has not addressed HIV/AIDS in depth and scope, even though its structures position it better in such a fight: NOUN can either take a leadership role or endanger itself considering its numerical strength and geographical spread. (Contains 6 tables.)