This report synthesizes a number of national studies that show the intentional abuse of prescription drugs to get high is a growing concern, particularly among teens. The analysis shows that teens are turning away from street drugs and using prescription drugs to get high. New users of prescription drugs have caught up with new users of marijuana. Next to marijuana, the most common illegal drugs teens are using to get high are prescription medications. Teens are abusing prescription drugs because they believe the myth that these drugs provide a medically safe high. The majority of teens get prescription drugs easily and for free, often from friends or relatives. Girls are more likely than boys to intentionally abuse prescription drugs to get high. Pain relievers such as OxyContin and Vicodin are the most commonly abused prescription drugs by teens. Adolescents are more likely than young adults to become dependent on prescription medication. An appendix providing definitions and an annotated reference list conclude this report.