This study sought to measure the relationship between national culture and the usability of an e-Learning system by using Hofstede's cultural dimensions and Nielson's usability attributes. The study revealed that high uncertainty avoidance cultures found the system more frustrating to use. The study also revealed that individuals from cultures with low power distance indicators (e.g., people more accepting of uneven power distribution) rated the system's usability higher than individuals from high power distance cultures. (Contains 6 tables.) [For complete proceedings, see ED491481.]