In this paper, research about mediated communication is used to shed light on questions that have arisen in relation to behavioral telehealth about the relative merits of different modes of distance communication for the transaction of behavioral telehealth services. The paper is in two parts. The first part contains a presentation of questions and issues about mediated communication that have been posed by behavioral telehealth researchers. In the second part, research about mediated communication from the fields of information science; group communication; social psychology; human-computer interaction; applied communication research; computer-mediated communication; business management; special education; and telephone communication is used to clarify the questions and issues presented in part one. (Contains 53 references) (Author/ADT)