This study evaluates the first year of a novel HIV and substance use prevention program for inner city youth (Offering New Youth eXperiences--ONYX). Baseline and follow-up measures of knowledge, attitudes, and risk behaviors were administered seven months apart to 441 youth participating in the ONYX program. Youth (n=71) who provided data at both baseline and follow-up assessments are reported on here. Significant reduction in risk behavior was not observed, however improvement in other outcomes was noted. Youths knowledge about HIV significantly increased from baseline to follow-up. Further, increases in condom use self-efficacy, perceived harm from drug use, and resistance of peer pressure to drink alcohol were observed. Overall, the results of this feasibility phase suggest that the design is possible and the program may be effective in producing some of the desired outcomes. (Author)