For more than a decade, the Substance Abuse and Mental Health Services Administrations Center for Substance Abuse Prevention (CSAP) has supported demonstration programs designed to identify interventions that work with populations at high risk to prevent substance abuse, delay its onset, and reduce substance abuse-related behaviors. Research now confirms that interventions aimed at reducing the risk factors and increasing the protective factors linked to substance abuse and related problem behavior can produce immediate and long-term positive results. Substance abuse is a complex problem that develops in response to multiple influences. Spheres of activity within the community--typically called domains--include the individual, family, peer, school, community, and society/environment. Each domain presents an opportunity for preventive action. This document presents a comprehensive compilation of both proven and promising interventions in an easy-to-scan grid, organized by risk factor and domain. For each intervention, the grid also includes information on target age, Institute of Medicine (IOM) prevention classification, program outcome, and the strategies specified in the Substance Abuse Prevention and Treatment (SAPT) block grant legislation. (Contains 63 references.) (GCP)