This booklet is designed to help educators by explaining the most effective principles for preventing HIV/AIDS. It focuses on aspects of learning and behavior that may be found in most cultures in varying degrees. The booklet provides guidance on how to develop and implement an effective school-based program for education on HIV/AIDS prevention. Ten chapters focus on: (1) "Professionally Trained and Actively Involved Educators"; (2) "Establish Partnerships"; (3) "Utilize Non-Conventional Methods of Teaching"; (4) "Introduce Open Communication"; (5) "Innovative Teaching Sessions"; (6) "Gender-Specific Approaches"; (7) "Dealing with Culturally Sensitive Content"; (8) "The Value of Peer-Based Support"; (9) "Skill-Based Education"; and (10) "Monitoring and Evaluation." Web resources on AIDS are included. (Contains 25 references.) (SM)