This report is designed to inform the residents of Denver and the rest of Colorado about the dimensions of the problems caused by alcohol, tobacco, and other drugs in the states capital city. The report focuses on: the prevalence of substance abuse and addiction in Denver; the adverse impact of substance abuse on the health and well-being of Denver residents; crime related to alcohol and illicit drugs; the economic costs of substance abuse; and city and state responses to these problems. It is noted that while substance abuse is a nationwide problem, its consequences are felt most acutely in individual neighborhoods, and policy responses play out in local settings that vary enormously. This report provides the latest available information on Denver, complemented whenever possible by national and state data to provide a comparative perspective. The report concludes with recommendations to guide future progress. (Contains 45 references)(GCP)