This publication is part of a series prepared in cooperation with the National Science Teachers Association (NSTA), the American Association for the Advancement of Science (AAAS), and the National Council of Teachers of Mathematics (NCTM), by the Eisenhower National Clearinghouse for Mathematics and Science Education. This document focuses on the groundbreaking activities of the Scope, Sequence and Coordination (SS&C) Project initiated by NSTA. This project is a science curriculum reform movement designed to help teachers make their science programs more interesting and relevant to student needs. The document describes the basic premises on which the SS&C project is built, the programs at various sites that have been part of the project's implementation, and the results and ongoing efforts at those sites. It also offers advice on how to implement and overcome major obstacles on an SS&C program. (MKR)