Developments in the field of brain research that focus on how humans learn is beginning to influence the way schools are being built and renovated. This report discusses how the brain learns, explores how this knowledge can be used to inform learning theory, and describes what instruction would be like in a brain-based learning environment as well as the implications on facility design. School designs incorporating house concepts, technology networks, and flexible spaces are examples of designs that are compatible with brain-based learning. Concluding comments provide the questions facility planners should ask their clients who wish to implement some of these design approaches to create brain-based learning environments. (GR)