The use of tobacco products is one of the most critical health problems facing the country. Through the use of neuroimaging technologies, it is now possible to see some of the changes in brain functioning that occur from smoking. There may be other chemicals in cigarette smoke that contribute to addiction. The improved understanding of addiction, along with the identification of nicotine as an addictive drug, has been instrumental in the development of medications and behavioral management treatments for nicotine addiction. The combination of scientific information and treatment strategies presented in this report provide current knowledge needed for intervention and prevention efforts in the medical and mental health services. (Contains 14 references.) (JDM)