One of a series of booklets on disability research, this paper explores two major developments in the application of information technology: health care informatics and knowledge management. Both of these concepts focus on maximizing the value of, and access to, information resources. Both use technology to create interactive systems through which a range of individuals and groups can potentially find, exchange, augment, and use information. Informatics, however, primarily looks outward, at consumers, clients, and patients, seeking ways to provide information, products, and services that can make health care more effective and efficient. In contrast, knowledge management looks inward, seeking ways to improve the scope, utility, and efficiency of knowledge within the organization. The first section of the paper discusses health care informatics and functional applications of informatics systems such as online databases, electronic journals, online support groups, computer-based patient record systems, disease management systems, and customer relationship management systems. Individuals who use these systems, and the benefits and advantages to health care informatics are reviewed, along with issues regarding access and information quality and reliability. The second part of the booklet explores knowledge management, how it works, and the importance of knowledge management within a disability research organization. (Contains 30 references.) (CR)