Clozapine is an antipsychotic medication used in the treatment of schizophrenia. This paper reviews articles concerning clozapine therapy. It considers its benefits and dangers in various situations, and how it can be successfully combined with talk therapies. Studies are reviewed concerning patients in outpatient clinics, partial hospitalization programs, and full hospitalization programs. The reviews conclude that neither drug therapy nor talk therapy alone is sufficient. The collusion of patient, doctor, and family is necessary if a successful resolution of the patient's problem is to be obtained. (JDM)