This study examines the effectiveness of the Too Good for Drugs II (TGFD II) program in impacting adolescents' substance use intentions, attitudes, and perceptions. Sixth grade students (N=1,318) from six middle schools in a large Florida school district participated in the pretest and posttest phase of the study. Posttest questionnaires were administered at the end of the first 9-week period immediately following the delivery of the prevention curriculum and again 20 weeks after the treatment delivery period. The TGFD II program evidenced positive effects on sixth-grade students' intentions to use tobacco, alcohol, and marijuana. The program was also successful in impacting students' risk and protective factors in the areas of Perceptions of Peer Resistance Skills; Positive Attitudes toward Non-Drug Use; Perceptions of Peer Normative Substance Use; Perceptions of Peer Disapproval of Substance Use; Association with Prosocial Peers; and Perceptions of Locus of Control/Self Efficacy. Treatment effects were examined for students participating in the program across gender, ethnic background, and socioeconomic status. The findings suggest that the program was equally effective for students regardless of gender, race, or economic status. (Contains 31 references.) (JDM)