The prevalence of suicidality among gay, lesbian, and bisexual youth is considerably higher than the reported rates for heterosexual youth. The strongest predictors for suicidality among all youth are substance abuse; victimization; social isolation; and exposure to suicide attempts or completion among family members. Homosexual and bisexual youth show significantly elevated rates for these risk factors. In addition, these youth experience other contributing risk factors for suicidality that differentiates them from heterosexual youth. The strongest predictors for suicidality, unique for sexual-minority youth, are gender non-conformity and younger age at time of homosexual identity formation. The population-based studies reviewed provided limited information about the association between religion and suicidality among youths. There is not just one risk factor most predictive of suicidal behavior among gay, lesbian, and bisexual youth, just as there is not for heterosexual youth. More likely it is the experience of multiple risk factors simultaneously in combination with low rates of protective factors that exacerbate suicidality among homosexual youth. It is hoped that the findings in this report might lead to the development of preventive interventions by identifying particular risk factors among these youth. (Contains 2 tables and 53 references.) (JDM)