In this study the efficacy of the Minnesota Multiphasic Personality Inventory 2 (MMPI-2) was examined with a Colombian college student population. It was projected that the participants would have elevated scales related to psychological distress, marginality, and poor morale, given the current socio-political climate in Columbia. Participants were university students (men=21; women=54) from Bogota, Columbia. Similarities and differences between male and female participants were examined on the Spanish version of the MMPI-2. Three conclusions can be drawn from the results. First, women were more likely to present issues related to interpersonal relationships and physical/somatic complaints, suggesting they are more internally conscious. Second, men were more likely to repress feelings related to anger and hostility and to report a sense of disconnectedness or alienation towards society, implying internalized anger and frustration. Third, differences were found on two of the traditional clinical scales; women obtained higher scores on the Masculinity Femininity and Psycopathic Deviant scales. These elevated scores suggest a more non-traditional sex role attitude in females than their male counterparts, and possible adaptive features to the stress related to their enrollment at the university or their ability to manage stress within Colombian society. (JDM)