This document is a guide to producing city profiles of alcohol, tobacco, and other drug problems. Adequate data are necessary to design interventions and local drug strategies tailored to the area, and profiles meet this need. Although each city is unique, the steps required to produce a profile are predictable. The guide describes five essential phases for producing city profiles of alcohol, tobacco, and other drugs. It connects the goals for each project phase to specific steps, including key decisions, challenges, and strategies related to each goal. The phases are: (1) getting started; (2) gathering data; (3) investigating programs; (4) producing the report; and (5) looking ahead. The guide also contains examples of standard forms that Drug Strategies has found useful in conducting profile research. (Contains 51 references.) (SLD)