This paper describes the University of South Carolina Professional Development School (PDS) Partnership Network. The first section examines initiation of a partnership for educational renewal, implementation of threshold conditions, institutionalization of the PDS, and the current period of transition as a new period of institutionalization has been initiated. This section also presents a literature review on the subject of PDSs. The second section presents outcomes and methods of the University of South Carolina's PDS effort, offering perspectives from key stakeholders (the executive director of the partnership and clinical experiences, a teacher leader, a principal, and an interim dean from the University). The paper concludes that collaboration involves hard work by all of the stakeholders. To initiate and sustain the necessary energy to actualize partnerships for educational renewal, stakeholders from all sectors of the learning community must be involved and committed to the goals of simultaneous renewal. Relationships must be built and nurtured. (Contains 32 references.) (SM)