This issue brief explores emerging efforts to meet the needs of infants and toddlers in low-income families. It highlights general strategies that states and localities can use to promote the healthy development of infants and toddlers in the context of promoting parental economic self-sufficiency. These strategies are illustrated with examples of state and local policies, programs, and partnerships that address access and quality issues related to infant and toddler care, stimulate strong and nurturing parent-child relationships, and also support low-income parents with very young children who are in or moving into the workforce. The brief concludes by providing a framework for initiatives addressing the needs of infants and toddlers in the context of welfare reform: (1) enhance the basic quality of child care for infants and toddlers throughout the community; (2) pay attention to nonprofessionals caring for babies; (3) build multi-disciplinary, community wide systems of care for infants and toddlers and their families, based on communities' existing resources; (4) develop programs to address the multiple needs of families with babies beyond enhancing parenting skills; (5) use TANF funding to support services for infants and toddlers in families receiving, transitioning from, or trying to avoid the need for cash assistance; and (6) create partnerships across systems and auspices. (EV)