The partnership described focuses on a severe problem with environmental pollution at Akwesasne, the Mohawk reservation situated along the St. Lawrence River, at the juncture of New York, Quebec, and Ontario. Industries are located along the river and its tributaries and in past years have discharged PCBs (and other toxins) into the waterways in and near the reservation. The community residents are very concerned about the effects of the toxic intrusion into their previously harmonious relationship with the natural environment. Community members worry that Akwesasne children may have been exposed in utero from accumulated maternal PCBs, from being breast fed, or from their own diet or contact with the water or adjacent air. The study described concerns the effects of PCBs on the physical, sexual, cognitive, and social development of adolescents at Akwesasne. The research questions address the relationship between the adolescents' exposure to PCBs (assessed by diet history), body burden of particular congeners (types) of PCBs (assessed by blood analysis), and their physical, sexual, cognitive, and social/behavioral functioning. The collaborative process between the community members and the researchers is detailed, focusing on the three principles of respect, equity, and empowerment. (Contains 13 references.) (GCP)