This publication presents case studies of 12 diverse Wisconsin school districts that developed and implemented comprehensive school health programs (CSHPs) using Wisconsin's Framework for Comprehensive School Health Programs. The Framework helps schools organize multiple strategies to promote positive youth development using six components: healthy school environment; curriculum, instruction, and assessment; pupil services; student programs; adult programs; and family and community connections. Researchers collected data from the featured districts via a preliminary questionnaire; onsite interviews with relevant staff, community members, and students; examination of relevant documents (e.g., strategic plans, grant applications, program descriptions, and curricular materials); and follow-up interviews. The results highlight several factors that contributed to the success of the programs, including district leadership; family and community partnership; inclusion of CSHPs in district-wide strategic planning; funding support; staff development and technical support; starting with a limited focus; needs/assets assessment; and focus on integrated curriculum. (SM)