This paper describes ergonomics and the need to adapt worksites and technologies for individuals with physical or sensory disabilities. It provides suggestions for how to design an appropriate setup, design considerations, environmental considerations, chairs, monitor height, ambient noise, light, and electricity. Recommendations include: (1) interview users about their specific needs and learn about the latest ergonomic design characteristics; (2) assess the physical and sensory abilities of the individuals, including his or her posture, arm and hand placements, backrest, and lumbar support; (3) review illumination, space and time; (4) provide adjustable desktops to allow adjustments for adults and students of all sizes and physical impairments; (5) allow users to pick a chair that best fits individual needs; and (6) reduce noise from printers, fans, and air conditioning, system cooling, and power supply units. Hazards such as pesticide oxidation and ozone emission are also discussed. Web site information is provided for four organizations that have information on topics related to ergonomic design. (CR)