Intended for use on national, state, and local levels, the ideas and data in this reference are organized by means of the Prevention Enhancement Protocols System (PEPS). This is a systematic process for evaluating evidence from prevention research and practice, which can then be developed into recommendations for practice. Chapter topics are: (1) "Substance Abuse Problems and the Status of the American Family," including "the extent of the problem" and "critical issues for families and children"; (2) "Risk and Protective Factors and Developmental Models in the Etiology of Substance Abuse"; (3) "Analysis of Evidence and Recommendations for Practice," which discusses "classification of preventive measures and description of approaches," and presents three major approaches with abstracts and recommendations for practice and reviews both research and practice evidence for each approach; (4) "Program Development and Delivery of Family-Centered Prevention Approaches"; (5) "Emerging Areas of Research and Practice," which includes a discussion of the constructs "Resilience" and "Family Support." Appendixes are: "Research and Practice Search Protocols,""Methodology,""Collateral Areas of Interest,""Abbreviations and Glossary," and "Resource Guide." (EMK)