This guide explains why the humanities are important in school-to-work systems and how high schools can develop one of two types of programs integrating humanities coursework and career exploration: the study of humanities as a way to enrich individuals' work lives and the study of humanities as career fields in their own right. The first half of the guide profiles the 3 humanities-based career exploration programs that were awarded the designation "Lighthouse" (model) site in U.S. Department of Education and Labor Regions VIII, IX, and X and the 29 sites that received honorable mention. The three Lighthouse programs are as follows: a series of experiential education programs integrating research, writing, literature, and issues surrounding Montana's heritage and public lands; a way-finding academy tying hands-on activities to careers related to the Hawaiian environment; and an applied English program highlighting various career options. The guide's remaining 3 sections contain the following: state frameworks, suggested activities, and sample projects for teaching global economics; lists of 15 relevant organizations, 23 online resources, 30 curricula and guides, 33 recommended publications, and the state humanities councils in the 12 states in regions VIII-X; and planning questions and a planning matrix for career pathways. (MN)