The Regional Educational Laboratory Program is the U.S. Department of Education's largest research-and-development investment designed to help educators, policy makers, and communities improve schools. Administered by the Office of Educational Research and Improvement (OERI), the network of 10 regional labs works to ensure that lessons about school reform developed or learned in one site can be appropriately applied elsewhere, and that everyone involved in educational improvement will have access to the best available research, knowledge from practice, and exemplary and promising programs. This handbook describes each laboratory's mission, key initiatives, ongoing work, and "signature programs"; provides examples of recent, high-quality materials selected from the many publications and products available from each lab; and previews each lab's website. Contact information for each lab is also provided. The labs include the Northeast and Islands Laboratory at Brown University (LAB), the Mid-Atlantic Laboratory for Student Success (LSS), the Appalachia Educational Laboratory (AEL), SouthEastern Regional Vision for Education (SERVE), the North Central Regional Educational Laboratory (NCREL), the Southwest Educational Development Laboratory (SEDL), the Mid-continent Regional Educational Laboratory (McREL), WestEd, the Northwest Regional Educational Laboratory (NWREL), and the Pacific Resources for Education and Learning (PREL). (LMI)