This paper provides a brief overview of Problem-Based Learning (PBL) as an instructional methodology. A description of a graduate program for practicing teachers at the University of Colorado at Denver (UCD) is also included. Problem-based learning is a student-centered instructional methodology that teaches content and skills within a knowledge domain by using substantive, carefully-crafted problems or challenges as the stimulus and focus for student activity. The students work with problems in a manner that fosters reasoning and knowledge application. The master's program in information and learning technologies at UCD is designed for classroom teachers using PBL as their primary instructional strategy. The main emphasis of the program is to help teachers learn to integrate information and learning technologies in student-centered ways in the classroom. Program issues, problems, successes, and lessons learned are discussed, including: group size and student-teacher ratio, infrequent class meetings, projects versus problems, project time commitment, and assessment and grading. (Author/SWC)