This document reports on a science education reform program sponsored by the Howard Hughes Medical Institute. The program is an attempt to overhaul the reform efforts of the Montgomery County Public Schools in Maryland, and participation in the project has been underway since 1994. Funds from the institute support teacher training in the use and evaluation of curricular materials, a summer science camp for middle school girls, an outdoor environmental education program for students and teachers, a week-long summer program for biology teachers at the outdoor education site on the Chesapeake Bay, the Holiday Lectures on Science Series, and programs that provide state-of-the-art training in molecular biology and chemistry. Program details are provided on the Holiday Lectures on Science; precollege science education grants in the Washington, D.C. metropolitan area; regional awards in the national grants program in the Washington, D.C. and Baltimore areas; the 1995-1996 participants in institute-funded projects in the Washington, D.C. and Baltimore areas; and background information about the Howard Hughes Medical Institute. (DDR)