In this study, a programmatic decision-making framework called the consensus marker-outcome variable system (CMOVS) was developed as a result of a comprehensive "meta-review" and synthesis of research on variables considered by experts to be important to learning for all students, including those with special needs or those at risk of failing. The CMOVS systematically analyzes program design and implementation features, assesses them in relation to site-specific needs, and provides a basis for calculating informational indexes. The information derived from the CMOVS can then be used to assist stakeholders in programmatic decision making. The first section of the paper provides an overview of the CMOVS framework, which groups 228 identified variables into 6 categories: (1) state and district variables; (2) out of school contextual variables; (3) school-level variables; (4) student variables; (5) program design variables; and (6) implementation, classroom instruction, and climate variables. The second section focuses on the research base for the design of the decision-making framework including the literature review and a Delphi survey of experts and practitioners. The final section provides detailed sample illustrations of the use of the CMOVS as a conceptual guide for making programming decisions. This section also shows how the CMOVS can be used to develop a Program Effectiveness Index and a Desirability of Implementation Index. Appended are the master list of variables; definitions; consensus from the field; and a CMOVS computer analysis of user ratings of selected, innovative educational practices. (Contains 13 references.) (Autor/DB)