The Regional Educational Laboratory Program is the U.S. Department of Education's largest research and development investment. Administered by the Office of Educational Research and Improvement (OERI), the network of 10 Regional Labs works to ensure that those involved in educational improvement at the local, state, and regional levels have access to the best available research and knowledge from practice. This handbook describes each Laboratory's mission and major activities and describes overall program goals, including how they serve their regions and network on a national basis. Information on how to contact the Laboratory or the OERI program officer for that Laboratory is provided. A map depicting the region that each Laboratory serves is included. (LMI)