The chapters of this report provide a starting point for the development of authentic prevention strategies for use in the African-American community, specifically for high risk youth. It is neither a "how to" manual nor a mandate for specific program details, but it does highlight the key components of alcohol and other drug abuse prevention. The following chapters are included: (1) "Background and Scope of the Alcohol and Other Drug Problem" (Lawford L. Goddard); (2) "Familial Precursors to Drug Abuse" (Lawford L. Goddard); (3) "Political and Economic Implications of Alcohol and Other Drugs in the African-American Community" (Omowale Amuleru-Marshall); (4) "Issues of Biological Vulnerability in AOD Abuse for the African-American Community" (Patricia A. Newton); (5) "Alcohol and Other Drug Abuse Literature, 1980-1989: Selected Abstracts" (Lawford L. Goddard); (6) "The Complex Nature of Prevention in the African-American Community: The Problem of Conceptualization" (Milton Morris); (7) "Natural Resistors in AOD Abuse Prevention in the African-American Family" (Lawford L. Goddard); (8) "Spirituality in the African-American Community" (Janet Pinkett); (9) "An Afrocentric Intervention Strategy" (Leonard C. Long); (10) "Prevention and Intervention Programs Targeted toward African-American Youth at High Risk" (Robert J. Courtney, Jr.); (11) "Site Visit Report of Three OSAP Grants Targeting African-American Youth at High Risk" (Lawford L. Goddard); (12) "An African-Centered Model of Prevention for African-American Youth at High Risk" (Wade W. Nobles and Lawford L. Goddard); and (13) "Selected African-Centered Readings" (Wade W. Nobles, Lawford L. Goddard, William E. Cavil, and Pamela Y. George). References follow each chapter, and a 167-item bibliography is included. An attachment lists key concepts and definitions related to these issues. Nine figures and two exhibits illustrate the discussions. (SLD)