This journal issue focuses on family service clinical responses to infants and families. In "The Therapeutic Relationship as Human Connectedness," Jeree H. Pawl stresses the importance of caregivers creating in children the sense and experience of human connectedness that arises from the feeling of existing in the mind of someone else--that is, being noticed, spoken to, protected, appreciated. In "'She Does Love Me, Doesn't She?'" Deborah J. Weatherston describes a program in which infant mental health specialists provide in-home services to infants and families that are psychologically and socially at-risk for neglect or abuse. Important support strategies are also identified. In "Using the Principles of Infant-Parent Psychotherapy To Change the Context for Children at Risk," Brenda P. Jones demonstrates that what clinicians do will matter to families at high environmental and individual risk, and that a clinician can deal with psychological issues and adapt traditional methods for families at risk; three primary therapeutic principles are identified. In "A Home-Based, Family Systems Approach to the Treatment of African-American Teenage Parents and Their Families," JoAnn Tatum and others describe a home-based family therapy program for adolescent parents and their extended families. The article suggests cultural issues relating to families and systemic intergenerational family issues relating to teen pregnancy must be discussed in relation to the African-American experience. In "The Interweaving of Neuropsychological Dysfunction and Psychological Conflict," Lois M. Black argues that neuropsychological conditions (brain-based dysfunctions) play a role in children's behavior and development, and that neuropsychological dysfunction and psychological conflict interact. Annotated lists of publications and videotapes included. Some articles contain references. (TM)