In 1993, "Signs of Effectiveness in Preventing Alcohol and Other Drug Problems" appeared. It addressed alcohol and other drug use as a health problem influenced by risk factors in five life spheres or domains: individual, family, school, peer group, and community. Like its predecessor, "Signs of Effectiveness II" reports on promising prevention strategies implemented in communities throughout the United States by Center for Substance Abuse Prevention's (CSAP) High-Risk Youth Demonstration grantees. Each project, which is profiled here, has been in operation long enough to provide an experience base that can be a resource to others. Some of the programs offer positive outcome data, while others, in spite of limited results, enjoy recognition in their communities as important, meaningful, and valued approaches. The main text is divided into the five major domains noted above. In each of these sections there is a description of factors that place youth at high risk for use of alcohol, tobacco, or other drugs; promising strategies that address these risk factors; and illustrations of effective strategies that have been implemented. The text contains numbered citations of specific curriculums, researchers, and program materials. The notes also provide contact information. There is detailed information about each of the High-Risk Youth Demonstration Grants, with names and addresses of people to notify for more information. (RJM)