Based on the business practices of the Maricopa County Community College District (MCCCD), in Arizona, this handbook provides an overview of activities involved in starting up a new or continuing grant. The handbook begins with the negotiation process but focuses primarily on events after the grant is funded. Following a brief overview of the grant process, the following sections are provided: (1) negotiating with government funding agencies, including handling the initial call and several negotiating strategies; (2) the negotiator's responsibilities as a grants administrator, including a list of the files that must be maintained and a general account of the administrator's responsibilities; (3) key contacts for administrators at the college, district, state, and federal levels; (4) preparing for managing the grant, discussing the proposal, budgets, regulations, and notice of award; (5) managing supplies, equipment, and travel and hiring personnel; (6) hiring, reassigning, and supervising personnel; (7) managing the grant's funding; (8) time and records management; (9) preparing and revising the operational budget; (10) writing grant reports; (11) closing out the grant; (12) avoiding common errors; and (13) preparing for an audit. Appendixes cover MCCCD Governing Board grants policy, board action items and acceptance forms, responsibilities of the District Director of Grants Development and Management, a grant writer's checklist, proposal planning and writing, tips for developing successful proposals, matching funds for grants, helpful MCCCD phone numbers, grant terminology, and monthly grant time records. (MAB)