Whether for use in a special methods course in teaching chemistry or a general methods course in teaching science, this guidebook is designed to assist the methods instructor in the task of fitting the ChemSource materials into the established patterns of the course. Each of three sections contains a number of units that accommodate the patterns of most methods courses. Each unit contains an introduction to the topic; some organization and implementation strategies; the identification of specific module/episode locations from the ChemSource materials; and useful resources. Unit topics include: (1) philosophy of instruction; (2) instructional objectives; (3) daily lesson planning; (4) longterm planning; (5) management, motivation, and self esteem; (6) beginning the activity, lesson, or unit; (7) ending the activity, lesson, or unit; (8) models and analogies; (9) demonstrations; (10) questioning; (11) pacing instruction; (12) peer learning; (13) laboratory learning; (14) safety; (15) problem solving; (16) educational technology; (17) contemporary issues and decision making; (18) assessment; and (19) professional development. Appendices include an example of a course syllabus for a science methods course, and sample student assignments. (LZ)