This guide provides a framework for creating and using learning centers to meet specific classroom goals, and presents ideas for topics and activities. The first part of the guide: (1) explains what learning centers are and how they are used within classrooms; (2) provides design options for the classroom; (3) suggests ways in which to schedule groups of children; and (4) provides evaluative suggestions and sample evaluation forms. The second part concentrates on activities and lessons, including a 5-day plan for the first week of class, lesson topics, and sample activities to use throughout the year. The guide concludes with answers to 10 frequently asked questions about classroom learning centers, and a list of companies that provide commercially prepared activities, supplies, and teacher resources suitable for learning centers. (SW)