Although much of traditional psychology assumes that a spiritual orientation is largely a matter of choice, it is contended here that such choices are embedded in the rich fabric of the cultural framework. This study explores a quantitative and qualitative contrast between Caucasian and Native American alcoholics on dimensions of spiritual development. Fifty self-reported, Caucasian alcoholics, and 37 self-reported Native American alcoholics and non-alcoholics, were administered the Spiritual Well-Being Scale. Additionally, two separate focus group interviews were conducted with selected samples of Native American and Caucasian alcoholics. Quantitative results showed no significant differences between the two groups in terms of spiritual, religious, and/or existential well-being. However, the focus groups revealed some potentially important thematic differences between the culturally diverse groups. Important cultural themes, which integrate spirituality and recovery from alcoholism, are outlined. The study identified two limitations in conducting research on alcoholism and spirituality among culturally diverse groups: the difficulty in obtaining large sample sizes, and the large standard deviations for both groups, suggesting the heterogeneity of spiritual development of recovering alcoholics. Implications for further qualitative inquiry and psychotherapeutic practice are made. (RJM)