This study investigates the interaction of religious and quasi-religious variables through measures of psychopathology and alcohol and drug abuse in a sample of homeless subjects. Participants included 25 males and 14 females with potential dual diagnoses who lacked, or were in danger of being without, appropriate housing. Researchers administered a battery of instruments to assess subjects' demographics, substance abuse history, religious thinking, psychopathology, attitudes toward life and death, and behavioral and personality issues. Findings demonstrated the utility of religious and quasi-religious instruments as indicators of psychopathology in the mentally ill and homeless. Subjects were highly prone to alcoholism and expressed little enthusiasm for living. The study indicates that church groups that care for the homeless should exercise caution in evaluating the homeless individual's expressions of religiosity or lack thereof. It appears that traditional rehabilitative efforts based upon the spiritual approach of Alcoholics Anonymous are likely to experience a lower success rate among the mentally-ill homeless due to the latter's alienation from religious beliefs. Further research questions are suggested. Also included are four tables which offer correlations and mean scores of findings. (RJM)