This curriculum guide encourages students to learn behaviors that will reduce the potential for Human Immunodeficiency Virus (HIV) infection when confronted with choices at a later age. The curriculum is designed for integration within a comprehensive program of school health education (in grades 6-8, lessons on communicable disease, including HIV, can interface with language arts, mathematics, vocational education, social studies, and life science units) and offers opportunities for students to practice sequential, age-appropriate decision-making skills. In addition to classroom lessons and the concomitant teacher resources and worksheets, the guide offers information for all school personnel as well as for classroom teachers; provides a historical perspective and other facts on HIV/AIDS; presents the rationale for HIV prevention education; discusses classroom strategies; and provides guidelines for ensuring appropriateness and efficacy for diverse student populations. Appendices include a glossary of terms, additional resources on HIV/AIDS and other communicable diseases, guidelines for effective HIV education, discussions of legal issues and policy development, universal precautions, illustrations for transparencies, and listings to teacher resources which contain approximately 100 references to print materials, 50 to video sources, and 50 to national and Texas organizations. (LL)