In recognition of the close relationship between motor skill and cognitive development in the first 2 years of life, this guide presents 78 developmentally appropriate activities that parents and teachers can use to enhance infant and toddler motor development. Activities are categorized by age group as follows: (1) 16 activities for newborn to 5-month-old infants (sample activities include: texture pictures, cooing together, colors and movement, people pictures, everyday singing, side to side eye movement); (2) 12 activities for 5-month to 9-month-old infants (sample activities include: peek-a-boo pictures, pulling strings, hide and seek, patting pans); (3) 13 activities for 9-month to 12-month-old infants (sample activities include: sprays of color, jack-in-the-box, reaching ribbon, sound identification); (4) 21 activities for 12-month to 18-month-old young toddlers (sample activities include: naming others, surprise board, bug jar, train pull, squeeze toys); and (5) 16 activities for older toddlers, aged 18 to 24 months (sample activities include naming game, carry on, pour and fill, block drop, ring around the animal). For each activity, the ability the child will be developing is identified and a brief description of procedures is provided. (BCY)