This curriculum guide to teaching secondary students about Acquired Immune Deficiency Syndrome (AIDS) using an interdisciplinary approach includes lessons that are meant to supplement the existing curriculum, but may be used to supplant existing lessons. Most of the lessons employ the investigative approach to learning and require student involvement. The curriculum includes lessons from the following content areas: computers and related technologies (8 lessons on graphics, databases, word processing, publishing, and videodiscs); language arts (10 lessons on short stories, speech, dramatic reading, advertising, note taking, debate, and other topics); mathematics (13 lessons on graphs, percents, matrix equations, ratios, and other topics); science (10 lessons on virus/infection, transmission, immune system, prevention, medical advances, epidemics, terminology, and sexually transmitted diseases); and social studies (13 lessons on debating, epidemics, geography, sociology, Bill of Rights, current events, history, economics, and peer pressure). Each lesson includes an objective, a list of resource materials, and a list of activities and culminating activities. Other materials include suggestions for student projects, an AIDS pretest, blackline masters for student handouts, a glossary, and a list of resources. (JDD)